Article
Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas.
Endocrine-related cancer - 1 Oct 2015
Åkerström Tobias, Willenberg Holger Sven, Cupisti Kenko, Ip Julian, Backman Samuel, Moser Ana, Maharjan Rajani, Robinson Bruce, Iwen K Alexander, Dralle Henning, D Volpe Cristina, Bäckdahl Martin, Botling Johan, Stålberg Peter, Westin Gunnar, Walz Martin K, Lehnert Hendrik, Sidhu Stan, Zedenius Jan, Björklund Peyman, Hellman Per
Abstract excerpt
Aldosterone-producing adenomas (APAs) are found in 1.5-3.0% of hypertensive patients in primary care and can be cured by surgery. Elucidation of genetic events may improve our understanding of these tumors and ultimately improve patient care. Approximately 40% of APAs harbor a missense mutation in the KCNJ5 gene. More recently, somatic mutations in CACNA1D, ATP1A1 and ATP2B3, also important for membrane...
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