Article
HLA-B is the best candidate of susceptibility genes in HLA for Japanese ulcerative colitis.
Tissue antigens - 1 Jun 2009
Aizawa H, Kinouchi Y, Negoro K, Nomura E, Imai G, Takahashi S, Takagi S, Kakuta Y, Tosa M, Mochida A, Matsumura Y, Endo K, Shimosegawa T
Abstract excerpt
Recently, a genome-wide association study for ulcerative colitis (UC) in the UK population was reported, and several susceptibility loci including the human leukocyte antigen (HLA) region were identified. The strongest association in the HLA region was found at a 400 kb haplotype block containing HLA-DRB1. In Japanese population, previous study suggested the association between UC and HLA-B*52; however, HLA...
Topics
- Adolescent
- Adult
- Case-Control Studies
- Colitis, Ulcerative
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- HLA-B Antigens
- HLA-DR Antigens
- HLA-DRB1 Chains