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Article

FLT3-TKD Mutations Associated With NPM1 Mutations Define a Favorable-risk Group in Patients With Acute Myeloid Leukemia.

Clinical lymphoma, myeloma & leukemia - 1 Dec 2018

Perry Marielle, Bertoli Sarah, Rocher Clément, Hayette Sandrine, Ducastelle Sophie, Barraco Fiorenza, Labussière-Wallet Hélène, Salles Gilles, Recher Christian, Thomas Xavier, Paubelle Etienne

Abstract excerpt

BACKGROUND: Outcome of patients with mutation of the FLT3 tyrosine kinase domain (FLT3-TKD) in acute myeloid leukemia (AML) remains controversial. PATIENTS AND METHODS: Herein, we present a retrospective study of 126 newly diagnosed patients with AML performed in 2 French centers. RESULTS: FLT3-TKD mutations represented 12.7% of patients, whereas FLT3-internal tandem duplication (ITD) mutation was observed in...

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Source

Identifiers

PMID: 30082225
DOI: 10.1016/j.clml.2018.06.006

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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