Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ZFYVE26/SPASTIZIN: a close link between complicated hereditary spastic paraparesis and autophagy.

Autophagy - 1 Feb 2014

Vantaggiato Chiara, Clementi Emilio, Bassi Maria Teresa

Abstract excerpt

Defective autophagy is associated with neurodegenerative disorders including Alzheimer, Parkinson and Huntington diseases, amyotrophic lateral sclerosis and SCA (spinocerebellar ataxias). Autophagy defects were detected also in SPG49, a complicated form of hereditary spastic paraparesis (cHSP) associated with mutations in the TECPR2 gene, suggesting a role of autophagy also in this heterogeneous group of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Autophagy
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to Neurodegenerative Diseases

Share to Paraparesis, Spastic

Share to Phagosomes

Share to Sequestosome-1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 24284334
DOI: 10.4161/auto.27173
PMCID: PMC5396092

Genes

ZFYVE26
SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ZFYVE26/SPASTIZIN: a close link between complicated hereditary spastic paraparesis and autophagy.PMID 24284334Read ↗

ZFYVE26/SPASTIZIN and SPG11/SPATACSIN mutations in hereditary spastic paraplegia types AR-SPG15 and AR-SPG11 have different effects on autophagy and endocytosis.Semantic proximity Read ↗

Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15.Semantic proximity Read ↗

Rescue of lysosomal function as therapeutic strategy for SPG15 hereditary spastic paraplegiaSemantic proximity Read ↗

TECPR2: a new autophagy link for neurodegeneration.Semantic proximity Read ↗

Investigating ZFYVE26 mutations in a Taiwanese cohort with hereditary spastic paraplegia.Semantic proximity Read ↗

Lysosomal abnormalities in hereditary spastic paraplegia types <scp>SPG</scp> 15 and <scp>SPG</scp> 11Semantic proximity Read ↗

A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system.Semantic proximity Read ↗

Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome.Semantic proximity Read ↗

Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic ParaplegiaSemantic proximity Read ↗

SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum.Semantic proximity Read ↗

Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformationSemantic proximity Read ↗

A tecpr2 knockout mouse exhibits age-dependent neuroaxonal dystrophy associated with autophagosome accumulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.