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Lysosomal abnormalities in hereditary spastic paraplegia types <scp>SPG</scp> 15 and <scp>SPG</scp> 11

20 May 2014

Abstract excerpt

OBJECTIVE: Hereditary spastic paraplegias (HSPs) are among the most genetically diverse inherited neurological disorders, with over 70 disease loci identified (SPG1-71) to date. SPG15 and SPG11 are clinically similar, autosomal recessive disorders characterized by progressive spastic paraplegia along with thin corpus callosum, white matter abnormalities, cognitive impairment, and ophthalmologic abnormalities....

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PMID: 24999486
DOI: 10.1002/acn3.64

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