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Article

Rescue of lysosomal function as therapeutic strategy for SPG15 hereditary spastic paraplegia

27 Aug 2022

Abstract excerpt

SPG15 is a hereditary spastic paraplegia subtype caused by mutations in Spastizin, a protein encoded by the ZFYVE26 gene. Spastizin is involved in autophagosome maturation and autophagic lysosome reformation and SPG15-related mutations lead to autophagic lysosome reformation defects with lysosome enlargement, free lysosome depletion and autophagosome accumulation. Symptomatic and rehabilitative treatments are the...

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PMID: 36029068
DOI: 10.1093/brain/awac308

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