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Article

Naringenin and SMER28 target lysosomal reformation and rescue SPG11 and SPG15 hereditary spastic paraplegia phenotypes.

Pharmacological research - 1 Aug 2025

Vantaggiato Chiara, Guarato Giulia, Brivio Francesca, Panzeri Elena, Speltoni Beatrice, Gumeni Sentiljana, Orso Genny, Santorelli Filippo Maria, Bassi Maria Teresa

Abstract excerpt

SPG11 and SPG15 are two hereditary spastic paraplegia forms characterized by autophagosome accumulation, reduced free lysosomes and defects in autophagic lysosomal reformation (ALR). We demonstrated that attempts to rescue ALR and/or lysosome biogenesis are critical strategies for SPG15 phenotype and that SMER28 improved lysosomal reformation rescuing locomotor deficit in a SPG15 Drosophila model. Here we...

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Identifiers

PMID: 40550407
DOI: 10.1016/j.phrs.2025.107836

Genes

SPG11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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