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Article

Senescence induction universally activates transposable element expression

18 Jul 2018

Abstract excerpt

Senescent cells constitutively secrete inflammatory cytokines, known as the senescence-associated secretory phenotype (SASP). Previous work has implicated SASP in immune-mediated clearance of senescent cells; however, its regulation remains unknown. Our recent transcriptome profiling study has shown that human senescent human stem and progenitors (s-HSPCs) robustly express genomic transposable elements (TEs) and...

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PMID: 30080431
DOI: 10.1080/15384101.2018.1502576

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