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Article

Effect of Taiwan mutation (D7H) on structures of amyloid-β peptides: replica exchange molecular dynamics study.

The journal of physical chemistry. B - 31 Jul 2014

Truong Phan Minh, Viet Man Hoang, Nguyen Phuong H, Hu Chin-Kun, Li Mai Suan

Abstract excerpt

Recent experiments have shown that the Taiwan mutation (D7H) slows the fibril formation of amyloid peptides Aβ40 and Aβ42. Motivated by this finding, we have studied the influence of D7H mutation on structures of Aβ peptide monomers using the replica exchange molecular dynamics simulations with OPLS force field and implicit water model. Our study reveals that the mechanism behind modulation of aggregation rates...

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PMID: 25010208
DOI: 10.1021/jp503652s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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