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Article

Impact of Mutations at C-Terminus on Structures and Dynamics of Aβ40 and Aβ42: A Molecular Simulation Study.

The journal of physical chemistry. B - 4 May 2017

Linh Nguyen Hoang, Minh Thu Tran Thi, Tu LyAnh, Hu Chin-Kun, Li Mai Suan

Abstract excerpt

Alzheimer's disease is presumed to be caused by the formation of intracellular plaques of amyloid β (Aβ) peptides inside neurons. The most abundant Aβ forms are Aβ40 and Aβ42 comprising, respectively, 40 and 42 residues. Recent experiments showed that the triple Gly33Val-Val36Pro-Gly38Val (VPV) mutation causes Aβ42 to become "super-Aβ42" with elevated aggregation rates and toxicity. Upon VPV mutation,...

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Identifiers

PMID: 28414234
DOI: 10.1021/acs.jpcb.6b12888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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