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Article

TRAF3IP2 (Act1/CIKS) variants: A domain to phenotype framework and therapeutic implications.

Cytokine & growth factor reviews - 1 Oct 2026

Alt Eckhard U, Izadpanah Reza

Abstract excerpt

Interleukin-17 (IL-17) family cytokines drive protective mucocutaneous immunity and, when dysregulated, a broad spectrum of inflammatory and autoimmune disease; almost all IL-17 receptor signaling converges on a single cytoplasmic adaptor, TRAF3IP2 (Act1/CIKS). This 574-amino-acid protein and U-box E3 ubiquitin ligase couples the IL-17 receptor to NF-κB and mitogen-activated protein kinase activation and also...

Read the complete abstract on PubMed

Topics

Humans
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Signal Transduction
Animals
Phenotype
Interleukin-17

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Receptors, Interleukin-17

Adaptor Proteins, Signal Transducing

Source

Identifiers

PMID: 42632295
DOI: 10.1016/j.cytogfr.2026.08.003

Genes

TRAF3IP2
TRAF6
TRAF2
TRAF3
TRAF5

Variants

rs33980500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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TRAF3IP2 (Act1/CIKS) variants: A domain to phenotype framework and therapeutic implications.PMID 42632295Read ↗

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