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Article

Genotype instability during long-term subculture of lymphoblastoid cell lines.

Journal of human genetics - 1 Jan 2013

Oh Ji Hee, Kim Young Jin, Moon Sanghoon, Nam Hye-Young, Jeon Jae-Pil, Lee Jong Ho, Lee Jong-Young, Cho Yoon Shin

Abstract excerpt

Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) promise to address the challenge posed by the limited availability of primary cells needed as a source of genomic DNA for genetic studies. However, the genetic stability of LCLs following prolonged culture has never been rigorously investigated. To evaluate genotypic errors caused by EBV integration into human chromosomes, we isolated genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23171997
DOI: 10.1038/jhg.2012.123

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