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Inactivation of KhpB (EloR/Jag) in Lactococcus cremoris increases uptake of the compatible solute glycine-betaine and enhances osmoresistance.

Applied and environmental microbiology - 22 Oct 2025

Xiang Yuwei, Pham Huong Thi, Gumulya Yosephine, Liang Zhao-Xun, Marcellin Esteban, Turner Mark S

Abstract excerpt

The second messenger cyclic-di-AMP (c-di-AMP) is a signaling molecule widely present in gram-positive bacteria, where it regulates osmotic resistance by controlling potassium and compatible solute transport. Our previous studies using a Lactococcus cremoris model strain demonstrated that mutants with elevated c-di-AMP can overcome osmosensitivity through mutations enhancing potassium transporter activity. To...

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PMID: 40960315
DOI: 10.1128/aem.00914-25
PMCID: PMC12542702

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