Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenomic Profile and Adverse Drug Reactions in a Prospective Therapeutic Cohort of Chagas Disease Patients Treated with Benznidazole.

International journal of molecular sciences - 16 Feb 2021

Franco Lucas A M, Moreira Carlos H V, Buss Lewis F, Oliveira Lea C, Martins Roberta C R, Manuli Erika R, Lindoso José A L, Busch Michael P, Pereira Alexandre C, Sabino Ester C

Abstract excerpt

Chagas disease remains a major social and public health problem in Latin America. Benznidazole (BZN) is the main drug with activity against Trypanosoma cruzi. Due to the high number of adverse drug reactions (ADRs), BZN is underprescribed. The goal of this study was to evaluate the genetic and transcriptional basis of BZN adverse reactions. METHODS: A prospective cohort with 102 Chagas disease patients who...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brazil
Share to Chagas Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Nitroimidazoles

Share to Transcriptome

Share to Trypanocidal Agents

Share to Trypanosoma cruzi

Source

Open in PubMed Open full text

Identifiers

PMID: 33669428
DOI: 10.3390/ijms22041960
PMCID: PMC7920452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenomic Profile and Adverse Drug Reactions in a Prospective Therapeutic Cohort of Chagas Disease Patients Treated with Benznidazole.PMID 33669428Read ↗

Evaluation of cytokine profile and HLA association in benznidazole related cutaneous reactions in patients with Chagas disease.Semantic proximity Read ↗

Adverse Drug Reactions to Anti-TB Drugs: Pharmacogenomics Perspective for Identification of Host Genetic Markers.Semantic proximity Read ↗

Trypanosoma cruzi DTU diversity, benznidazole response, and clinical manifestations of Chagas disease: a seventeen-year systematic review and meta-analysis.Semantic proximity Read ↗

Genetic polymorphisms and adverse reactions to antituberculosis therapySemantic proximity Read ↗

Genome-Wide Association Studies for Idiosyncratic Drug-Induced Hepatotoxicity: Looking Back-Looking Forward to Next-Generation Innovation.Semantic proximity Read ↗

Incidence and associated risk factors of antituberculosis drug induced hepatotoxicity among TB patientsSemantic proximity Read ↗

Thyrotropin receptor antibodies and a genetic hint in antithyroid drug-induced adverse drug reactions.Semantic proximity Read ↗

Antituberculosis Drug-Induced Adverse Events in the Liver, Kidneys, and Blood: Clinical Profiles and Pharmacogenetic Predictors.Semantic proximity Read ↗

The study of severe cutaneous drug hypersensitivity reactions from a systems biology perspective.Semantic proximity Read ↗

NR1I2 genetic polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity: A systematic review and meta-analysis.Semantic proximity Read ↗

Pharmacogenomic screening strategy and indicative screening efficiency for antithyroid drug-induced agranulocytosis in the Southern Han Chinese.Semantic proximity Read ↗

Adverse drug reactions associated with the use of biological agentsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.