Article

The Interplay Between Molecular Architecture, Pharmacology, and Suspected Adverse Drug Reactions Associated with Non-Steroidal Androgen Antagonists in The United Kingdom

2024-07-09

Abstract excerpt

<h4>Aims</h4> To correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed non-steroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off-target polypharmacology. <h4>Methods</h4> Physiochemical and polypharmacology data was curated from the Electronic Medicines Compendium, FDA New Drug Applications documents, and ChEMBL databases. Syst...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab214bde-52c0-5b0b-8633-4915852e57ad
DOI: 10.1101/2024.07.09.24309949

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Interplay Between Molecular Architecture, Pharmacology, and Suspected Adverse Drug Reactions Associated with Non-Steroidal Androgen Antagonists in The United KingdomDOI 10.1101/2024.07.09.24309949Read

Research Progress on High-Risk Drugs for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis with Insights from Adverse Drug Reaction Database MiningSemantic proximity Read

A Real-World Disproportionality Analysis of Two Typical First-Generation TRK Inhibitors: Findings from the FDA Adverse Event Reporting System DatabaseSemantic proximity Read

A real-world pharmacovigilance study of FDA adverse event reporting system (FAERS) events for TivozanibSemantic proximity Read

An opportunity for clinical pharmacology trained physicians to improve patient drug safety: A retrospective analysis of adverse drug reactions in teenagersSemantic proximity Read

Drug hypersensitivity: Pharmacogenetics and clinical syndromesSemantic proximity Read

Adverse event profile differences between Trastuzumab Emtansine and Trastuzumab Deruxtecan: a real-world, pharmacovigilance studySemantic proximity Read

Adverse Event Profiles of CDK4/6 inhibitors: A pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) databaseSemantic proximity Read

Demographics, Overlap, and Latency of Severe Cutaneous Adverse Reactions in an FDA DatabaseSemantic proximity Read

Safety assessment of S-1: Real-world adverse event analysis from the FAERS databaseSemantic proximity Read

Adverse drug reactions associated with the use of biological agentsSemantic proximity Read

Pharmacoepidemiology of autoimmune diseasesSemantic proximity Read

Risks associated with the combination of Darolutamide and Docetaxel in interstitial lung disease : a pharmacovigilance study based on the FAERS databaseSemantic proximity Read