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Caveolin-1 temporal modulation enhances trastuzumab and trastuzumab-drug conjugate efficacy in heterogeneous gastric cancer

2021-07-14

Abstract excerpt

<h4>ABSTRACT</h4> Resistance mechanisms and heterogeneity in HER2-positive gastric cancers (GC) limit trastuzumab benefit in 32% of patients, and other targeted therapies have failed in clinical trials. Using genomic data from patient tissue, patient-derived xenografts (PDXs), partially humanized biological models, and HER2-targeted imaging we identified caveolin-1 (CAV1) as a complementary biomarker in GC select...

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Literature Corpus work
98a00062-e74b-59f9-91d0-13bd17b57df9
DOI
10.1101/2021.07.13.452260
Open publication

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