Article
CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jul 2024
Herrera-Pariente Cristina, Bonjoch Laia, Muñoz Jenifer, Fernàndez Guerau, Soares de Lima Yasmin, Mahmood Romesa, Cuatrecasas Miriam, Ocaña Teresa, Lopez-Prades Sandra, Llargués-Sistac Gemma, Domínguez-Rovira Xavier, Llach Joan, Luzko Irina, Díaz-Gay Marcos, Lazaro Conxi, Brunet Joan, Castillo-Manzano Carmen, García-González María Asunción, Lanas Angel, Carrillo Marta, Hernández San Gil Raquel, Quintero Enrique, Sala Nuria, Llort Gemma, Aguilera Lara, Carot Laura, Diez-Redondo Pilar, Jover Rodrigo, Ramon Y Cajal Teresa, Cubiella Joaquín, Castells Antoni, Balaguer Francesc, Bujanda Luis, Castellví-Bel Sergi, Moreira Leticia
Abstract excerpt
BACKGROUND: CDH1 and CTNNA1 remain as the main genes for hereditary gastric cancer. However, they only explain a small fraction of gastric cancer cases with suspected inherited basis. In this study, we aimed to identify new hereditary genes for early-onset gastric cancer patients (EOGC; < 50 years old). METHODS: After germline exome sequencing in 20 EOGC patients and replication of relevant findings by gene-panel...
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