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Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models

15 Jun 2022

Abstract excerpt

Objective Cell-cell (CC) and cell-matrix (CM) adhesions are essential for epithelial cell survival, yet dissociation-induced apoptosis is frequently circumvented in malignant cells. Design We explored CC and CM dependence in 58 gastric cancer (GC) organoids by withdrawing either ROCK inhibitor, matrix or both to evaluate their tumorigenic potential in terms of apoptosis resistance, correlation with oncogenic...

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PMID: 35705367
DOI: 10.1136/gutjnl-2022-327121

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