Article
Detection of circulating tumour cell clusters in human glioblastoma.
British journal of cancer - 1 Aug 2018
Krol Ilona, Castro-Giner Francesc, Maurer Martina, Gkountela Sofia, Szczerba Barbara Maria, Scherrer Ramona, Coleman Niamh, Carreira Suzanne, Bachmann Felix, Anderson Stephanie, Engelhardt Marc, Lane Heidi, Evans Thomas Ronald Jeffry, Plummer Ruth, Kristeleit Rebecca, Lopez Juanita, Aceto Nicola
Abstract excerpt
Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularised malignant brain cancer. Individual circulating tumour cells (CTCs) are sporadically found in GBM patients, yet it is unclear whether multicellular CTC clusters are generated in this disease and whether they can bypass the physical hurdle of the blood-brain barrier. Here, we assessed CTC presence and composition at multiple time...
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