Circulating tumor cell clusters: Insights into tumour dissemination and metastasis

Abstract excerpt

Introduction: Metastasis results in more than 90% of cancer-related deaths globally. The process is thought to be facilitated by metastatic precursor cells, commonly termed circulating tumor cells (CTCs). CTCs can exist as single cells or cell clusters and travel through the lymphovasculature to distant organs where they can form overt metastasis.Areas covered: Studies have highlighted that CTC clusters, which...

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