Article

Precision single-cell profiling of Circulating Tumour Cells: novel markers and data-driven characterization by CTCeek

2026-02-19

Abstract excerpt

Circulating tumour cells (CTCs) represent a minimally invasive method for monitoring cancer evolution in patients. CTCs are nowadays commonly isolated using antibodies against EPCAM protein. A key limitation regards the extent of EPCAM-negative CTCs, such as those that undergo EMT or whose tumour of origin is EPCAM-low or negative. We studied 3,302 RNA single-cell transcriptomes reported as CTCs in public reposito...

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Literature Corpus work: 67850e1f-1b38-5f26-9398-97eec63de0d8
DOI: 10.64898/2026.02.18.706522

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