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Article

Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE-/- mice fed western diet.

Scientific reports - 30 Jul 2018

Bedja Djahida, Yan Wenwen, Lad Viren, Iocco Domenica, Sivakumar Nickash, Bandaru Veera Venkata Ratnam, Chatterjee Subroto

Abstract excerpt

Sphingolipids have been accorded numerous biological functions however, the effects of feeding a western diet (diet rich in cholesterol and fat) on skin phenotypes, and color is not known. Here, we observed that chronic high-fat and high-cholesterol diet intake in a mouse model of atherosclerosis (ApoE-/-) decreases the level of ceramides and glucosylceramide. At the expense of increased levels of...

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Identifiers

PMID: 30061606
DOI: 10.1038/s41598-018-28663-9
PMCID: PMC6065400

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