Obesity resistance of the stearoyl-CoA desaturase-deficient (<i>scd1</i> ^-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation

Abstract excerpt

Targeted deletion of the stearoyl-CoA desaturase 1 gene (scd1) in mouse causes obesity resistance and a severe skin phenotype. Here, we demonstrate that SCD1 deficiency disrupts the epidermal lipid barrier and leads to uncontrolled transepidermal water loss, breakdown of adaptive thermoregulation and cold resistance, as well as a metabolic wasting syndrome. The loss of omega-hydroxylated very long-chain fatty...

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