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Article

Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.

Nature communications - 27 Jul 2018

Muliaditan Tamara, Caron Jonathan, Okesola Mary, Opzoomer James W, Kosti Paris, Georgouli Mirella, Gordon Peter, Lall Sharanpreet, Kuzeva Desislava M, Pedro Luisa, Shields Jacqueline D, Gillett Cheryl E, Diebold Sandra S, Sanz-Moreno Victoria, Ng Tony, Hoste Esther, Arnold James N

Abstract excerpt

Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also found in human breast cancer, represent a macrophage phenotype similar to that observed during the...

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Source

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Identifiers

PMID: 30054470
DOI: 10.1038/s41467-018-05346-7
PMCID: PMC6063977

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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