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Article

Tumor-associated macrophages secrete CCL2 and induce the invasive phenotype of human breast epithelial cells through upregulation of ERO1-α and MMP-9.

Cancer letters - 28 Nov 2018

Lee Seungeun, Lee Eunhye, Ko EunYi, Ham Mina, Lee Hye Min, Kim Eun-Sook, Koh Minsoo, Lim Hyun Kyung, Jung Joohee, Park So Yeon, Moon Aree

Abstract excerpt

Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that promote invasion and metastasis of cancer cells. In this study, we investigated the effect of TAMs on phenotypic conversion of non-neoplastic MCF10A human breast epithelial cells using an indirect co-culture system. Co-culture with TAMs induced epithelial-to-mesenchymal transition, invasive phenotype, and MMP-9 upregulation in...

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Source

Identifiers

PMID: 30165193
DOI: 10.1016/j.canlet.2018.08.025

Genes

CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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