Article
PGE2-HIF1α reciprocal induction regulates migration, phenotypic alteration and immunosuppressive capacity of macrophages in tumor microenvironment.
Life sciences - 15 Jul 2020
Saha Jayasree, Sarkar Debanjan, Pramanik Anik, Mahanti Krishna, Adhikary Arghya, Bhattacharyya Sankar
Abstract excerpt
BACKGROUND: Very little is known about the role inflammation and mechanism(s) that enables the tumor to evade host's anti-tumor immune function during very initial days of tumor establishment. Our study focuses on the immune response and local inflammation specially the pro-inflammatory and immune modifier components that are responsible for tumor-induced immune-suppression, tumor-associated macrophages (TAM) at...
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