Article
Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages.
Scientific reports - 18 Jul 2016
Huber Roman, Meier Barbara, Otsuka Atsushi, Fenini Gabriele, Satoh Takashi, Gehrke Samuel, Widmer Daniel, Levesque Mitchell P, Mangana Joanna, Kerl Katrin, Gebhardt Christoffer, Fujii Hiroko, Nakashima Chisa, Nonomura Yumi, Kabashima Kenji, Dummer Reinhard, Contassot Emmanuel, French Lars E
Abstract excerpt
Hypoxia is a hallmark of cancer that is strongly associated with invasion, metastasis, resistance to therapy and poor clinical outcome. Tumour hypoxia affects immune responses and promotes the accumulation of macrophages in the tumour microenvironment. However, the signals linking tumour hypoxia to tumour-associated macrophage recruitment and tumour promotion are incompletely understood. Here we show that the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.