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Article

Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jan 2013

Li You, Masaki Takahiro, Yamane Daisuke, McGivern David R, Lemon Stanley M

Abstract excerpt

Hepatitis C virus (HCV) replication is dependent on microRNA 122 (miR-122), a liver-specific microRNA that recruits Argonaute 2 to the 5' end of the viral genome, stabilizing it and slowing its decay both in cell-free reactions and in infected cells. Here we describe the RNA degradation pathways against which miR-122 provides protection. Transfected HCV RNA is degraded by both the 5' exonuclease Xrn1 and 3'...

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Identifiers

PMID: 23248316
DOI: 10.1073/pnas.1213515110
PMCID: PMC3562843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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