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Article

Enhanced detection of circulating tumor DNA by fragment size analysis

7 Nov 2018

Abstract excerpt

Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alterations but have rarely considered the biological properties of plasma cell-free DNA (cfDNA). We hypothesized that differences in fragment lengths of circulating DNA could be exploited to enhance sensitivity for detecting the presence of ctDNA and for noninvasive genomic analysis of cancer. We surveyed ctDNA...

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PMID: 30404863
DOI: 10.1126/scitranslmed.aat4921

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