Article
FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation.
The Journal of pathology - 1 Nov 2018
Foth Mona, Ismail Nur Faezah Binti, Kung Jeng Sum Charmaine, Tomlinson Darren, Knowles Margaret A, Eriksson Pontus, Sjödahl Gottfrid, Salmond Jonathan M, Sansom Owen J, Iwata Tomoko
Abstract excerpt
Recent studies of muscle-invasive bladder cancer show that FGFR3 mutations are generally found in a luminal papillary tumour subtype that is characterised by better survival than other molecular subtypes. To better understand the role of FGFR3 in invasive bladder cancer, we examined the process of tumour development induced by the tobacco carcinogen OH-BBN in genetically engineered models that express...
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