Article

FGFR3 activating mutations induce luminal-like papillary bladder tumor formation and favor a male gender bias

2021-09-03

Abstract excerpt

<h4>Background</h4> FGFR3 mutations are among the most frequent genetic alterations in bladder cancer and are enriched in the luminal papillary subtype of muscle-invasive tumors (MIBC) and luminal-like classes 1 and 3 of non-MIBC. To study their oncogenic properties in vivo , we developed here a genetically engineered mouse (GEM) model expressing the most frequent FGFR3 mutation, FGFR3-S249C, in urothelial cells...

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Literature Corpus work: 9811a359-6e70-5e7b-a431-551a5e030de7
DOI: 10.1101/2021.09.02.458778

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