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Article

Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice.

The Journal of pathology - 1 Jun 2014

Foth Mona, Ahmad Imran, van Rhijn Bas W G, van der Kwast Theodorus, Bergman Andre M, King Louise, Ridgway Rachel, Leung Hing Y, Fraser Sioban, Sansom Owen J, Iwata Tomoko

Abstract excerpt

Although somatic mutations and overexpression of the tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) are strongly associated with bladder cancer, evidence for their functional involvement in the pathogenesis remains elusive. Previously we showed that activation of Fgfr3 alone is not sufficient to initiate urothelial tumourigenesis in mice. Here we hypothesize that cooperating mutations are required...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PTEN Phosphohydrolase

Share to Receptor, Fibroblast Growth Factor, Type 3

Share to TOR Serine-Threonine Kinases

Share to Urinary Bladder

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Share to Urothelium

Source

Open in PubMed Open full text

Identifiers

PMID: 24519156
DOI: 10.1002/path.4334
PMCID: PMC4612374

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice.PMID 24519156Read ↗

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