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Article

Null mutation for macrophage migration inhibitory factor (MIF) is associated with less aggressive bladder cancer in mice.

BMC cancer - 24 Jul 2007

Taylor John A, Kuchel George A, Hegde Poornima, Voznesensky Olga S, Claffey Kevin, Tsimikas John, Leng Lin, Bucala Richard, Pilbeam Carol

Abstract excerpt

BACKGROUND: Inflammatory cytokines may promote tumorigenesis. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with regulatory properties over tumor suppressor proteins involved in bladder cancer. We studied the development of bladder cancer in wild type (WT) and MIF knockout (KO) mice given N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), a known carcinogen, to determine the role of MIF in...

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Source

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Identifiers

PMID: 17650334
DOI: 10.1186/1471-2407-7-135
PMCID: PMC1939709

Genes

MIF

Provenance

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