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Article

Hairy cell leukemia (HCL) and HCL-like disorders: present, emergent treatment options and future directions.

Expert review of hematology - 1 Dec 2024

Troussard Xavier

Abstract excerpt

INTRODUCTION: Hairy cell leukemia accounts for less than 2% of leukemias. The hairy cells express CD11c, CD25, CD103, and CD123 markers. The BRAFV600E mutation was detected in 95% of HCL cases. Patients achieve high complete response rate with purine analogues with or without rituximab, but relapses are inevitable. HCL-like disorders including HCL variant, splenic diffuse red pulp lymphoma, and splenic marginal...

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Identifiers

PMID: 39535173
DOI: 10.1080/17474086.2024.2427660

Genes

BRAF
BTK
CDA
MAP2K1

Provenance

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