Article
Regulation of the oncogenic phenotype by the nuclear body protein ZC3H8.
BMC cancer - 24 Jul 2018
Schmidt John A, Danielson Keith G, Duffner Emily R, Radecki Sara G, Walker Gerard T, Shelton Amber, Wang Tianjiao, Knepper Janice E
Abstract excerpt
BACKGROUND: The Zc3h8 gene encodes a protein with three zinc finger motifs in the C-terminal region. The protein has been identified as a component of the Little Elongation Complex, involved in transcription of small nuclear RNAs. ZC3H8 is overexpressed in a number of human and mouse breast cancer cell lines, and elevated mRNA levels are associated with a poorer prognosis for women with breast cancer. METHODS: We...
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