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Article

Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis.

Oncotarget - 10 Nov 2015

Lee Miyoung, Oprea-Ilies Gabriela, Saavedra Harold I

Abstract excerpt

The E2F transcriptional activators E2F1, E2F2 and E2F3a regulate many important cellular processes, including DNA replication, apoptosis and centrosome duplication. Previously, we demonstrated that silencing E2F1 or E2F3 suppresses centrosome amplification (CA) and chromosome instability (CIN) in Her2+ breast cancer cells without markedly altering proliferation. However, it is unknown whether and how silencing a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26512919
DOI: 10.18632/oncotarget.5686
PMCID: PMC4741932

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