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Article

Role of the chromobox protein CBX7 in lymphomagenesis.

Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2007

Scott Clare L, Gil Jésus, Hernando Eva, Teruya-Feldstein Julie, Narita Masako, Martínez Dolores, Visakorpi Tapio, Mu David, Cordon-Cardo Carlos, Peters Gordon, Beach David, Lowe Scott W

Abstract excerpt

Chromobox 7 (CBX7) is a chromobox family protein and a component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells and can act independently of BMI-1 to repress the INK4a/ARF tumor suppressor locus. To determine whether CBX7 might be oncogenic, we examined its expression pattern in a range of normal human tissues and tumor samples. CBX7 was expressed at high levels...

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Share to Lymphoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Loss of Heterozygosity

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Share to Polycomb Repressive Complex 1

Share to Proto-Oncogene Proteins c-myc

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Source

Open in PubMed Open full text

Identifiers

PMID: 17374722
DOI: 10.1073/pnas.0608721104
PMCID: PMC1828941

Genes

CBX7
PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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