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Article

Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine-DNA alkyltransferase: implications for the design of DNA-modifying drugs.

European journal of medicinal chemistry - 1 Mar 2006

Pletsas Dimitrios, Wheelhouse Richard T, Pletsa Vassiliki, Nicolaou Anna, Jenkins Terence C, Bibby Michael C, Kyrtopoulos Soterios A

Abstract excerpt

The protein O6-alkylguanine-DNA alkyltransferase (Atase) is responsible for the repair of DNA lesions generated by several clinically important anti-cancer drugs; this is manifest as active resistance in those cancer cell lines proficient in Atase expression. Novel O6-substituted guanine analogues have been synthesized, bearing acidic, basic and hydrogen bonding functional groups. In contrast to existing...

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Identifiers

PMID: 16458393
DOI: 10.1016/j.ejmech.2005.11.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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