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Article

Junctional membrane Ca2+ dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation.

Proceedings of the National Academy of Sciences of the United States of America - 7 Aug 2018

Cully Tanya R, Choi Rocky H, Bjorksten Andrew R, Stephenson D George, Murphy Robyn M, Launikonis Bradley S

Abstract excerpt

We used the nanometer-wide tubules of the transverse tubular (t)-system of human skeletal muscle fibers as sensitive sensors for the quantitative monitoring of the Ca2+-handling properties in the narrow junctional cytoplasmic space sandwiched between the tubular membrane and the sarcoplasmic reticulum cisternae in single muscle fibers. The t-system sealed with a Ca2+-sensitive dye trapped in it is sensitive to...

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Identifiers

PMID: 30038012
DOI: 10.1073/pnas.1800490115
PMCID: PMC6094124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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