Article
The couplonopathies: A comparative approach to a class of diseases of skeletal and cardiac muscle.
The Journal of general physiology - 1 Jun 2015
Ríos Eduardo, Figueroa Lourdes, Manno Carlo, Kraeva Natalia, Riazi Sheila
Abstract excerpt
A novel category of diseases of striated muscle is proposed, the couplonopathies, as those that affect components of the couplon and thereby alter its operation. Couplons are the functional units of intracellular calcium release in excitation-contraction coupling. They comprise dihydropyridine receptors, ryanodine receptors (Ca2+ release channels), and a growing list of ancillary proteins whose alteration may...
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