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Article

Germline mutations in young non-smoking women with lung adenocarcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2018

Donner Iikki, Katainen Riku, Sipilä Lauri J, Aavikko Mervi, Pukkala Eero, Aaltonen Lauri A

Abstract excerpt

OBJECTIVES: Although the primary cause of lung cancer is smoking, a considerable proportion of all lung cancers occur in never smokers. Gender influences the risk and characteristics of lung cancer and women are overrepresented among never smokers with the disease. Young age at onset and lack of established environmental risk factors suggest genetic predisposition. In this study, we used population-based sampling...

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Source

Identifiers

PMID: 30032850
DOI: 10.1016/j.lungcan.2018.05.027

Genes

BRCA1
BRCA2
CLIP4
ABCC10
CFTR
ERCC4
EXT1
GCN1
GJB6
PTCH1
RYR1
SMARCB1
TTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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