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Article

Clinical validation of molecular markers of macrocyclic lactone resistance in Dirofilaria immitis.

International journal for parasitology. Drugs and drug resistance - 1 Dec 2018

Ballesteros Cristina, Pulaski Cassan N, Bourguinat Catherine, Keller Kathy, Prichard Roger K, Geary Timothy G

Abstract excerpt

Prophylaxis with macrocyclic lactone (ML) endectocides is the primary strategy for heartworm control. Recent evidence has confirmed that ML-resistant Dirofilaria immitis isolates have evolved. Comparison of genomes of ML-resistant isolates show they are genetically distinct from wild-type populations. Previously, we identified single nucleotide polymorphisms (SNPs) that are correlated with phenotypic ML...

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Identifiers

PMID: 30031685
DOI: 10.1016/j.ijpddr.2018.06.006
PMCID: PMC6288007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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