Article
Genetic profiles of ten Dirofilaria immitis isolates susceptible or resistant to macrocyclic lactone heartworm preventives.
Parasites & vectors - 9 Nov 2017
Bourguinat Catherine, Keller Kathy, Xia Jianguo, Lepage Pierre, McTier Tom L, Woods Debra J, Prichard Roger K
Abstract excerpt
BACKGROUND: For dogs and cats, chemoprophylaxis with macrocyclic lactone (ML) preventives for heartworm disease is widely used in the United States and other countries. Since 2005, cases of loss of efficacy (LOE) of heartworm preventives have been reported in the U.S. More recently, ML-resistant D. immitis isolates were confirmed. Previous work identified 42 genetic markers that could predict ML response in...
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