Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance.

doi:10.1016/j.vetpar.2015.04.002

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Article

Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance.

Veterinary parasitology - 15 Jun 2015

Bourguinat Catherine, Lee Alice C Y, Lizundia Regina, Blagburn Byron L, Liotta Janice L, Kraus Marc S, Keller Kathy, Epe Christian, Letourneau Louis, Kleinman Claudia L, Paterson Tara, Gomez Elena Carreton, Montoya-Alonso José Alberto, Smith Hubert, Bhan Aron, Peregrine Andrew S, Carmichael James, Drake Jason, Schenker Rudolf, Kaminsky Ronald, Bowman Dwight D, Geary Timothy G, Prichard Roger K

Abstract excerpt

Macrocyclic lactone (ML) endectocides are used as chemoprophylaxis for heartworm infection (Dirofilaria immitis) in dogs and cats. Claims of loss of efficacy (LOE) of ML heartworm preventives have become common in some locations in the USA. We directly tested whether resistance to MLs exists in LOE isolates of D. immitis and identified genetic markers that are correlated with, and therefore can predict ML...

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PMID: 25936435
DOI: 10.1016/j.vetpar.2015.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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