PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications.

doi:10.1016/j.humpath.2018.07.006

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Article

PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications.

Human pathology - 1 Nov 2018

Luchini Claudio, Cros Jerome, Pea Antonio, Pilati Camilla, Veronese Nicola, Rusev Borislav, Capelli Paola, Mafficini Andrea, Nottegar Alessia, Brosens Lodewijk A A, Noë Michaël, Offerhaus G Johan A, Chianchiano Peter, Riva Giulio, Piccoli Paola, Parolini Claudia, Malleo Giuseppe, Lawlor Rita T, Corbo Vincenzo, Sperandio Nicola, Barbareschi Mattia, Fassan Matteo, Cheng Liang, Wood Laura D, Scarpa Aldo

Abstract excerpt

Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC), a variant of pancreatic ductal adenocarcinoma (PDAC), has a striking genetic similarity to PDAC but a significantly improved overall survival. We hypothesize that this difference could be due to the immune response to the tumor, and as such, we investigated the expression of PD-1, PD-L1, and CD163 in a series of UCOGC. To this aim, 27 pancreatic...

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PMID: 30031096
DOI: 10.1016/j.humpath.2018.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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