Article
Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma.
The Journal of pathology - 1 Oct 2017
Luchini Claudio, Pea Antonio, Lionheart Gemma, Mafficini Andrea, Nottegar Alessia, Veronese Nicola, Chianchiano Peter, Brosens Lodewijk Aa, Noë Michaël, Offerhaus G Johan A, Yonescu Raluca, Ning Yi, Malleo Giuseppe, Riva Giulio, Piccoli Paola, Cataldo Ivana, Capelli Paola, Zamboni Giuseppe, Scarpa Aldo, Wood Laura D
Abstract excerpt
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCOGC) is currently considered a morphologically and clinically distinct variant of pancreatic ductal adenocarcinoma (PDAC). In this study, we report clinical and pathological features of a series of 22 UCOGCs, including the whole exome sequencing of eight UCOGCs. We observed that 60% of the UCOGCs contained a well-defined epithelial...
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