Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotyping and clinical utility of phagocytic polyploid giant cancer macrophages in blood.

Cancer letters - 28 Oct 2025

Adams Daniel L, Cristofanilli Massimo, Lin Steven H, Bergan Raymond C, Ho Thai H, Marks Jeffrey R, Martin Stuart S, Edelman Martin J, Chumsri Saranya, Hager Elizabeth J, Tang Cha-Mei, Tsai Susan, Alpaugh R Katherine

Abstract excerpt

Historically, polyploid giant cancer cells (PGCCs) within tumors have been ignored as superfluous inflammatory refuse with no intrinsic clinical or biological relevance. However recently, multiple studies have described the existence PGCCs in solid tumor masses that appear to correlate with tumor progression, and can also appear in blood circulation as cancer associated macrophage like cells (CAMLs). In an effort...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Neoplasms

Share to Phagocytosis

Share to Phenotype

Share to Polyploidy

Share to Tumor-Associated Macrophages

Source

Open in PubMed Open full text

Identifiers

PMID: 40912599
DOI: 10.1016/j.canlet.2025.218007
PMCID: PMC13218590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotyping and clinical utility of phagocytic polyploid giant cancer macrophages in blood.PMID 40912599Read ↗

Understanding Polyploid Giant Cancer Cells: From Molecular Mechanisms to Clinical ImplicationsSemantic proximity Read ↗

Polyploid giant cancer cells and cancer progressionSemantic proximity Read ↗

Bizarre giant cells in human angiosarcoma exhibit chemoresistance and contribute to poor survival outcomesSemantic proximity Read ↗

Hypoxia-induced polypoid giant cancer cells in glioma promote the transformation of tumor-associated macrophages to a tumor-supportive phenotype.Semantic proximity Read ↗

Roles of Polyploid/Multinucleated Giant Cancer Cells in Metastasis and Disease Relapse Following Anticancer TreatmentSemantic proximity Read ↗

Emerging Paradigms in Cancer Metastasis: Ghost Mitochondria, Vasculogenic Mimicry, and Polyploid Giant Cancer CellsSemantic proximity Read ↗

Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumorsSemantic proximity Read ↗

Tissue‐Resident Macrophages in Cancer: Friend or Foe?Semantic proximity Read ↗

The curious phenomenon of dual-positive circulating cells: Longtime overlooked tumor cellsSemantic proximity Read ↗

Polyploid giant cancer cells and tumor budding: translation from basic research to clinical applicationSemantic proximity Read ↗

High-Dimensional Phenotyping of Human Myeloid-Derived Suppressor Cells/Tumor-Associated Macrophages in Tissue by Mass Cytometry.Semantic proximity Read ↗

Polyploid giant cancer cell characterization: New frontiers in predicting response to chemotherapy in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.