Article
K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium.
The American journal of surgical pathology - 1 Oct 1998
Westra W H, Sturm P, Drillenburg P, Choti M A, Klimstra D S, Albores-Saavedra J, Montag A, Offerhaus G J, Hruban R H
Abstract excerpt
Osteoclast-like giant cell tumors (OCGTs) of the pancreas and liver are enigmatic tumors. Despite their striking morphologic resemblance to certain mesenchymal tumors of bone and tendon sheath, it has been suggested that these tumors may, in fact, arise from epithelial precursors. It is also uncl...
Topics
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- Bile Ducts
- DNA Primers
- DNA, Neoplasm
- Epithelial Cells
- Genes, ras
- Giant Cell Tumors
- Giant Cells
- Humans
- Immunoenzyme Techniques
- Liver Neoplasms
- Macrophages
- Mutation