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Article

Lynch Syndrome Genetics and Clinical Implications.

Gastroenterology - 1 Apr 2023

Peltomäki Päivi, Nyström Minna, Mecklin Jukka-Pekka, Seppälä Toni T

Abstract excerpt

Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans and accounts for some 3% of unselected patients with colorectal or endometrial cancer and 10%-15% of those with DNA mismatch repair-deficient tumors. Previous studies have established the genetic basis of LS predisposition, but there have been significant advances recently in the understanding of the molecular pathogenesis of...

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Source

Identifiers

PMID: 36706841
DOI: 10.1053/j.gastro.2022.08.058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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