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Article

Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2009

Luu Van-Duc, Boysen Gunther, Struckmann Kirsten, Casagrande Silvia, von Teichman Adriana, Wild Peter J, Sulser Tullio, Schraml Peter, Moch Holger

Abstract excerpt

PURPOSE: The paired box gene 2, PAX2, encodes for a transcription factor that is up-regulated during nephrogenesis and becomes silenced in mature epithelium of the glomeruli, the proximal, and distal tubules. Reactivation of PAX2 has been frequently observed in clear cell renal cell carcinoma (cc...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19401348
DOI: 10.1158/1078-0432.CCR-08-2779

Genes

PAX2
VHL
CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19401348-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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